Pinkhassik, E. (2010).
Pacifichem 2010, International Chemical Congress of Pacific Basin Societies, Honolulu, HI, United States, December 15-20, 2010
We use lipid bilayers as supramol. self-assembled scaffolds for directed assembly of functional nanomaterials. Recently, we reported a simple method for controlling size, chem. environment, and d. of nanopores spanning nanometer-thin membranes. These membranes are characterized by tunable mol. wt. cut-off, extremely fast mass transfer, and long-term structural stability. Vesicle-templates polymer nanocapsules can retain medium-sized mols. such as pH-sensitive indicator dyes while providing uninhibited access for small mols. to the capsule interior. Nanocapsules showed no cytotoxicity. In one application, we use nanocapsules for targeted delivery of radiog. contrast agents and therapeutic agents to osteoarthritic lesions. In another application, we entrap catalysts within nanocapsules to combine high efficiency of homogeneous catalysts with ease of sepn. from reaction products.
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